Illustration of platform-specific errors. The panels show Artemis BAM views with reads (horizontal bars) mapping to defined regions of chromosome 11 of P. falciparum from PacBio (P; top), Ion Torrent (I; middle) and MiSeq (M; bottom). Red vertical dashes are 1 base differences to the reference and white points are indels. A) Illustration of errors in Illumina data after a long homopolymer tract. Ion torrent data has a drop of coverage and multiple indels are visible in PacBio data. B) Example of errors associated with short homopolymer tracts. Multiple insertions are visible in the PacBio Data, deletions are observed in the PGM data and the MiSeq sequences read generally correct through the homopolymer tract. C) Example of strand specific deletions (red circles) observed in Ion Torrent data.
Torrent Explain Pain Pdf
Torrent Pharma, the flagship Company of Torrent Group, with a turnover of Rs. 8508 Cr is one of the leading Pharma companies in the Country. We are the pioneers in initiating the concept of niche marketing in India and today is ranked amongst the leaders in therapeutic segment of cardiovascular (CV), central nervous system (CNS), gastro-intestinal (GI) and women healthcare (WHC). The Company also has significant presence in diabetology, pain management, gynaecology, oncology and anti-infective segments.
The MEDDIC sales qualification process is a framework of questions used to qualify prospects and potential buyers. It stands for Metrics, Economic buyer, Decision criteria, Decision process, Identify pain, and Champion.
The CARDTM System (Comfort, Ask, Relax, Distract) provides groups of strategies that you can play to cope with stressful situations. Originally used to help reduce fear and pain from medical procedures, CARDTM can also be used in situations that cause fear or anxiety.
To enable people in pain to understand more about their situation and to become less frightened of their pain. We know that the threat value of pain contributes directly to the pain experience and by informing people about what is actually happening inside them we can reduce the threat.
We think that one strength of this book is that anyone who suffers from persistent pain, or has a loved one, colleague or friend who has persistent pain, can directly benefit from using the book. The benefit will be greater with guidance from an informed clinician where necessary.
It is now known that understanding more about why things hurt can actually help people to overcome their pain. Recent advances in fields such as neurophysiology, brain imaging, immunology, psychology and cellular biology have provided an explanatory platform from which to explore pain. Explain Pain discusses how pain responses are produced by the brain: how responses to injury from the autonomic motor and immune systems in your body contribute to pain, and why pain can persist after tissues have had plenty of time to heal.
Over a decade ago, Explain Pain began a revolution in the treatment of pain. Now, fully revised and updated, Explain Pain Second Edition continues to be the leading resource for pain sufferers, clinicians and therapists wanting to gain a deep understanding of pain. With the publication of The Explain Pain Handbook: Protectometer, Explain Pain has never been more relevant and has been tightly integrated with our new book with extensive referencing throughout the Handbook.
While each book stands alone in its own right, the combination of Explain Pain Second Edition and The Explain Pain Handbook: Protectometer will provide the most in-depth and up to date pain education and treatment package available.
Piriformis syndrome accounts for approximately 6% of patients who present with sciatic pain. There are many treatment options ranging from physical therapy, to trigger point injections, to surgical intervention. We discuss a surgical method that represents a minimally invasive technique for the treatment of piriformis syndrome.
Early experience with our method of piriformis release suggests that it is well suited for the treatment of piriformis syndrome. The novel integration of pre-operative trigger point localization coupled with intraoperative neuromonitoring allows effective pain relief with minimal morbidity.
The treatment of PS has traditionally been conservative in nature with noninvasive treatment including activity modifications, physical therapy, and use of anti-inflammatory medications, muscle relaxants, and/or neuropathic pain medications [1, 5]. When patients fail conservative management, the next step in treatment is typically localized injections of either corticosteroids or botulinum neurotoxin into the piriformis muscle [5]. Surgical treatment of PS is reserved for patients that are refractory to conservative management. Current surgical methods to treat PS include open or endoscopic decompression of the sciatic nerve by release of the piriformis muscle [6]. The purpose of this paper is to describe a new minimally invasive surgical technique and its operative nuances that were used to treat 3 patients with PS.
The described surgical technique was performed in three patients who failed conservative management. The first patient was a 70-year-old female with a 3-year history of left buttock and leg pain. She underwent multiple lumbar epidural injection and two lumbar foraminotomies without any relief. She was found to have a trigger point in the region overlying the left piriformis musculature and sciatic nerve. She did not undergo EMG studies of her lower extremities at our facility. She failed conservative management with physical therapy and 2 trigger point injections with only temporary resolution of her symptoms. Given the resolution of her symptoms with trigger point injections, the decision was made to proceed with surgery.
The second patient was a 51-year-old female with a 1-year progressive history of right buttock pain that radiated down the right leg. Her lumbar MRI was negative, and she was found to have classic symptoms of PS including a trigger point at the piriformis musculature overlying the sciatic nerve on the right. She failed conservative management of physical therapy, medications, and trigger point injections. Her EMG findings were inconclusive. Given her continued pain and failure of conservative management, the decision was made to proceed with surgery.
The third patient was a 39-year-old female with a multi-year history of pain that started in her right buttocks and radiated down her right leg. She was diagnosed with PS and had a classic trigger point at the piriformis musculature overlying the sciatic nerve on the right. She failed conservative management with physical therapy and trigger point injections with only temporary relief. Her EMG results were inconclusive. However, given her temporary relief with the trigger point injections, the decision was made to proceed with surgery.
As an alternative to the above procedures, the minimally invasive approach described in this manuscript provides the advantages seen in both the traditional open and endoscopic methods. Our surgical approach provides excellent visualization of critical structures with minimal morbidity and short hospitalization. With the small incision and direct corridor to the nerve constriction, this minimally invasive approach can be mastered without requiring the steep learning curve as seen in the endoscopic approach. Most importantly, bleeding and injury to surrounding structures are less likely and easier to control as compared to the endoscopic method. Additionally, all three of our surgical procedures using this technique were performed as outpatient procedures with long-term pain relief without prolonged hospital stay and increased morbidity as seen in the traditional open surgical technique.
The person should not usually work or drive for the rest of the day because of the sedative effect of the medication used to prevent the pain. Any cognitive effects should be reported to a doctor prior to leaving the procedure area or after.
Manufacturers sometimes add acetaminophen or ibuprofen to products to help treat pain or fever. Some products also contain an antihistamine, which can help control coughing. However, antihistamines can cause drowsiness.
Torrent Pharmaceuticals operates in more than 40 countries with over 2000 product registrations globally. Torrent Pharma is active in the therapeutic areas of Cardiovascular (CV), central nervous system (CNS), gastro-intestinal, diabetology, anti-infective and pain management segments. It has also forayed into the therapeutic segments of nephrology and oncology while also strengthening its focus on gynecology and pediatric segments.Drug firm Torrent Pharmaceuticals on 23 July 2019 reported a 32.51 percent rise in its consolidated net profit to Rs 216 crore for the quarter ended 30 June, mainly on account of robust sales in most geographies.[2]
This may be known in some by the oppositionthey have to remaining at rest, and allowing themselvesto be led by the Spirit of God; by a confusionof faults and defects into which they fall withoutbeing conscious of them; or, if they are possessed ofnatural prudence, by a certain skill in concealing theirfaults from others and from themselves; by their[p 99] adherence to their sentiments, and by a number of otherindications which cannot be explained.
[p 113]It is to be remarked, that the river or torrent thusprecipitated into the sea does not lose its nature,although it is so changed and lost as not to be recognised.It will always remain what it was, yet itsidentity is lost, not as to reality, but as to quality; forit so takes the properties of salt water, that it hasnothing peculiar to itself, and the more it loses itselfand remains in the sea, the more it exchanges its ownnature for that of the sea. For what, then, is not thispoor torrent fitted? Its capacity is unlimited, sinceit is the same as that of the sea; it is capable ofenriching the whole earth. O happy loss! who canset thee forth? Who can describe the gain whichhas been made by this useless and good-for-nothingriver, despised and looked upon as a mad thing, onwhich the smallest boat could not be trusted, because,not being able to restrain itself, it would have draggedthe boat with it. What do you say of the fate of thistorrent, O great rivers! which flow with such majesty,which are the delight and admiration of the world,and glory in the quantity of merchandise spread outupon you? The fate of this poor torrent, which youregard with contempt, or at best with compassion,[p 114] what has it become? What use can it serve now, orrather, what use can it not serve? What does itlack? You are now its servants, since the richeswhich you possess are only the overflow of its abundance,or a fresh supply which you are carryingto it. 2ff7e9595c
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